Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity

• DOI: 10.1038/srep30820
• Publication Date: 2016-08-01T09:21:10Z
• Authors: A. B. Fagundo; S. Jiménez-Murcia; C. Giner-Bartolomé; Z. Agüera; S. Sauchelli; M. Pardo; A. B. Crujeiras; R. Granero; R. Baños; C. Botella; R. de la Torre; J. M. Fernández-Real; J. C. Fernández-G...; G. Frühbeck; A. Rodríguez; N. Mallorquí-Bagué; S. Tárrega; F. J. Tinahones; R. Rodriguez; F. Ortega; J. M. Menchón; F. F. Casanueva; F. Fernández-Aranda
• Keywords: Stroop effect; Executive dysfunction; Dysfunctional family

Abstract Whether the executive profile is different between obesity (OB) and morbid (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin recently discovered hormone associated with some of positive effects PA. The objective study was to investigate in OB MO, explore role PA irisin. 114 participants were included (21 OB, 44 MO 49 healthy controls-HC) assessed Wisconsin Card Sorting Test, Stroop Color Word Iowa Gambling Task. All female, aged 18 60 years. Results showed similar dysfunctional on decision making compared HC. Thus, no specific neuropsychological profiles be clearly observed our sample. However, negative correlation found irisin functioning. These results demonstrate relevant modulation Although might promising target for treatment obesity, its cognition considered when thinking about therapeutic use.