Discovery of parvovirus-related sequences in an unexpected broad range of animals

• DOI: 10.1038/srep30880
• Publication Date: 2016-09-07T09:35:35Z
• Authors: S. François; D. Filloux; P. Roumagnac; D. Bigot; P. Gayral; D. P. Martin; R. Froissart; M. Ogliastro
• Keywords: Human virome; Canine parvovirus; Viral evolution

Abstract Our knowledge of the genetic diversity and host ranges viruses is fragmentary. This particularly true for Parvoviridae family. Genetic studies single stranded DNA within this family have been largely focused on arthropod- vertebrate-infecting species that cause diseases humans our domesticated animals: a focus has biased perception parvovirus diversity. While metagenomics approaches could help rectify bias, so too transcriptomics studies. Large amounts transcriptomic data are available diverse array animal whenever inadvertently gathered from virus-infected individuals, it contain detectable viral transcripts. We therefore performed systematic search parvovirus-related sequences (PRSs) publicly transcript, genome protein databases eleven new transcriptome datasets. revealed 463 PRSs in transcript 118 animals. At least 41 these likely integrated genomes they were also found genomic sequence databases. Besides illuminating ubiquity parvoviruses, number parvoviral discovered public numerous previously unknown parvovirus-host combinations; invertebrates. findings suggest host-ranges extant parvoviruses might span entire kingdom.