Consciousness and cortical responsiveness: a within-state study during non-rapid eye movement sleep
Cerebral Cortex
Male
0301 basic medicine
Multidisciplinary
Neuronal Plasticity
Consciousness
Sleep, REM
Electroencephalography
ta3112
Synaptic Transmission
Transcranial Magnetic Stimulation
Article
Dreams
03 medical and health sciences
Non-REM sleep
Cerebral Cortex/physiology; Consciousness; Dreams/physiology; Electroencephalography; Female; Humans; Male; Neuronal Plasticity; Sleep/physiology; Sleep, REM/physiology; Synaptic Transmission; Transcranial Magnetic Stimulation; Wakefulness/physiology
Humans
Female
Wakefulness
Sleep
DOI:
10.1038/srep30932
Publication Date:
2016-08-05T10:57:19Z
AUTHORS (9)
ABSTRACT
Abstract When subjects become unconscious, there is a characteristic change in the way cerebral cortex responds to perturbations, as can be assessed using transcranial magnetic stimulation and electroencephalography (TMS–EEG). For instance, compared wakefulness, during non-rapid eye movement (NREM) sleep TMS elicits larger positive–negative wave, fewer phase-locked oscillations an overall simpler response. However, many physiological variables also when go from wake sleep, anesthesia, or coma. To avoid these confounding factors, we focused on NREM only measured TMS-evoked EEG responses before awakening asking them if they had been conscious (dreaming) not. As shown here, reported no experience upon awakening, evoked negative deflection shorter response dream. Moreover, amplitude of deflection—a hallmark neuronal bistability according intracranial studies—was inversely correlated with length dream report (i.e., total word count). These findings suggest that variations level consciousness within same state are associated changes underlying cortical circuits.
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