Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers

• DOI: 10.1038/srep30958
• Publication Date: 2016-08-02T09:11:24Z
• Authors: Huajun Xu; Xiaojiao Zheng; Yingjun Qian; Jian Guan; Hongliang Yi; Jianyin Zou; Yuyu Wang; Lili Meng; Aihua Zhao; Shankai Yin; Wei Jia
• Keywords: Xanthine; Metabolome

Abstract Few clinical studies have explored altered urinary metabolite levels in patients with obstructive sleep apnea (OSA). Thus, we applied a metabolomics approach to analyze metabolites three groups of participants: polysomnography (PSG)-confirmed OSA, simple snorers (SS) and normal subjects. Ultra-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry gas were used. A total 21 31 differentially expressed the SS OSA groups, respectively. Patients had 18 different from those SS. Of 56 detected among 3 24 consistently higher or lower. receiver operator curve analysis revealed that combination 4-hydroxypentenoic acid, arabinose, glycochenodeoxycholate-3-sulfate, isoleucine, serine xanthine produced moderate diagnostic score sensitivity (specificity) 75% (78%) for distinguishing without OSA. The 5-dihydrotestosterone sulfate, serine, spermine distinguished 85% specificity 80%. Multiple metabolic pathways associated identified using signatures could potentially serve as an alternative method PSG.