Predatory bacteria are nontoxic to the rabbit ocular surface

• DOI: 10.1038/srep30987
• Publication Date: 2016-08-16T10:31:46Z
• Authors: Eric G. Romanowski; Nicholas A. Stella; Kimberly M. Brothers; Kathleen A. Yates; Martha L. Funderb...; James L. Funderburgh; Shilpi Gupta; Sonal Dharani; Daniel E. Kadouri; Robert M. Q. Shanks
• Keywords: Pathogenic bacteria

Abstract Given the increasing emergence of antimicrobial resistant microbes and near absent development new antibiotic classes, innovative therapeutic approaches to address this global problem are necessary. The use predatory bacteria, bacteria that prey upon other is gaining interest as an “out box” treatment for multidrug pathogenic bacterial infections. Before a agent used treat infections, it must be tested safety. goal study was test tolerability on ocular surface using in vitro vivo models. Predatory Bdellovibrio bacteriovorus Micavibrio aeruginosavorus were found non-toxic human corneal stromal keratocytes ; however, they did induce production proinflammatory chemokine IL-8 but not IL-1β. inflammation rabbit eyes, with without epithelial abrasions. Unlike standard care vancomycin, inhibit wound healing or increase clinical inflammatory signs . Together these data support safety surface, future studies warranted regarding deeper tissues eye.