Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2

• DOI: 10.1038/srep31003
• Publication Date: 2016-08-30T09:20:46Z
• Authors: Hirotaka Matsuo; Tomoyuki Tsunoda; Keiko Ooyama; Masayuki Sakiyama; Tsuyoshi Sogo; Tappei Takada; Akio Nakashima; Akiyoshi Nakayama; Makoto Kawaguchi; Toshihide Higashino; Kenji Wakai; Hiroshi Ooyama; Ryota Hokari; Hiroshi Suzuki; Kimiyoshi Ichida; Ayano Inui; Shin Fujimori; Nariyoshi Shinomiya
• Keywords: Abcg2; Pathophysiology

Abstract To clarify the physiological and pathophysiological roles of intestinal urate excretion via ABCG2 in humans, we genotyped dysfunctional common variants, Q126X (rs72552713) Q141K (rs2231142), end-stage renal disease (hemodialysis) acute gastroenteritis patients, respectively. dysfunction markedly increased serum uric acid (SUA) levels 106 hemodialysis patients ( P = 1.1 × 10 −4 ), which demonstrated role for because their almost depends on ABCG2. Also, significantly elevated SUA 67 6.3 −3 ) regardless degree dehydration, gastroenteritis. These findings first time show ABCG2-mediated indicates importance epithelium as an pathway besides absorption pathway. Furthermore, could be a useful marker not only dehydration but also epithelial impairment intestine.