Identification of IL6 as a susceptibility gene for major depressive disorder

• DOI: 10.1038/srep31264
• Publication Date: 2016-08-09T09:10:38Z
• Authors: Chen Zhang; Zhiguo Wu; Guoqing Zhao; Fan Wang; Yiru Fang
• Keywords: SNP; Genetic Association

Abstract Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed comprehensive genetic study to determine the association between gene encoding IL6 ( ) and MDD in Han Chinese. There were 50 drug-naïve patients healthy controls undergoing an mRNA expression study. A sample of 772 with 759 used analysis. Next, eQTL analysis identify whether risk SNP(s) is associated brain. results showed have higher levels than P = 0.008). The SNP rs1800797 has significant 0.01) dominant model. marginally frontal cortex 0.087). preliminary findings are suggestive MDD. Further investigations required evaluate larger samples increase statistical power examine correlation methylation patterns.