Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study

• DOI: 10.1038/srep31479
• Publication Date: 2016-08-25T09:40:36Z
• Authors: Attila A. Seyhan; Yury O. Nunez Lopez; Hui Xie; Fanchao Yi; Clayton Mathews; Magdalena Pasarica; Richard E. Pratley
• Keywords: Prediabetes

Abstract The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers β-cell injury/dysfunction that would allow more accurate subtyping diabetes. We measured plasma levels selected miRNAs subjects with prediabetes (n = 12), type 2 (T2D, n 31), latent autoimmune adults (LADA, 6) and 1 (T1D, 16) compared them healthy control 27). study was conducted at Translational Research Institute for Metabolism Diabetes (TRI-MD), Florida Hospital. MiRNAs including miR-375 (linked injury), miR-21 (associated islet inflammation), miR-24.1, miR-30d, miR-34a, miR-126, miR-146, miR-148a were significantly elevated various forms controls. Levels several correlated glucose responses during oral tolerance testing, HbA 1c , function, insulin resistance controls, prediabetes, T2D. These data suggest linked injury inflammation distinguish between subtypes This information could used predict progression disease, guide selection optimal therapy monitor interventions, thus improving outcomes patients