Prosteatotic and Protective Components in a Unique Model of Fatty Liver: Gut Microbiota and Suppressed Complement System

• DOI: 10.1038/srep31763
• Publication Date: 2016-08-23T09:42:34Z
• Authors: Long Liu; Xing Zhao; Qian Wang; Xiaoxian Sun; Lili Xia; Qianqian Wang; Biao Yang; Yihui Zhang; Sean Montgomery; He Meng; Tuoyu Geng; Daoqing Gong
• Keywords: Steatosis

Abstract Goose can develop severe hepatic steatosis without overt injury, thus it may serve as a unique model for uncovering how steatosis-related injury is prevented. To identify the markedly prosteatotic and protective mechanisms, we performed an integrated analysis of liver transcriptomes gut microbial metagenomes using samples collected from overfed normally-fed geese at different time points. The results indicated that fatty transcriptome, initially featuring ‘metabolism’ pathway, was later joined by ‘cell growth death’ ‘immune diseases’ pathways. Gut microbiota played synergistic role in response genes affected overfeeding shared multiple Remarkably, complement system, inflammatory component, comprehensively suppressed liver, which partially due to increased blood lactic acid enriched Lactobacillus . Data vitro studies suggested TNFα via HNF1α/C5 pathway. In conclusion, microbes their hosts respond excess energy influx organic whole, related tolerance goose be attributable microbiotic products participates suppression TNFα/inflammation through