Raman Spectroscopic Analysis Reveals Abnormal Fatty Acid Composition in Tumor Micro- and Macroenvironments in Human Breast and Rat Mammary Cancer
Mammary Neoplasms, Experimental
Breast Neoplasms
Signal-To-Noise Ratio
Spectrum Analysis, Raman
Article
Rats
3. Good health
03 medical and health sciences
Mammary Glands, Animal
0302 clinical medicine
Fatty Acids, Unsaturated
Animals
Humans
Female
Breast
Rats, Wistar
DOI:
10.1038/srep32922
Publication Date:
2016-09-06T10:24:24Z
AUTHORS (7)
ABSTRACT
Fatty acids play essential roles in the growth and metastasis of cancer cells. To facilitate their avid proliferation, cells not only alter fatty acid synthesis metabolism intracellularly extracellularly, but also macroenvironment via direct or indirect pathways. We report here, using Raman micro-spectroscopy, that an increase production polyunsaturated (PUFAs) was identified both cancerous normal appearing breast tissue obtained from patients tumor-bearing rats. By minimizing confounding effects mixed chemicals optimizing signal-to-noise ratio spectra, we observed a large-scale transition monounsaturated to PUFAs tumor while small subset transitioned micro- macroenvironment. These data have important implications for further clarifying macroenvironmental effect progression provide new potential approaches characterizing pre-clinical animal studies clinical applications.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (49)
CITATIONS (33)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....