Regulation of cell-cell fusion by nanotopography

• DOI: 10.1038/srep33277
• Publication Date: 2016-09-12T10:01:47Z
• Authors: Jagannath Padmana...; Michael J. Augelli; Bettina Cheung; Emily R. Kinser; Barnett Cleary; Priyanka Kumar; Renhao Wang; Andrew J. Sawyer; Rui Li; Udo D. Schwarz; Jan Schroers; Themis R. Kyriakides
• Keywords: Nanotopography; Cell fusion

Abstract Cell-cell fusion is fundamental to a multitude of biological processes ranging from cell differentiation and embryogenesis cancer metastasis biomaterial-tissue interactions. Fusogenic cells are exposed biochemical biophysical factors, which could potentially alter behavior. While inducers such as cytokines kinases have been identified, little known about the regulation cell-cell fusion. Here, we designed experiments examine using bulk metallic glass (BMG) nanorod arrays with varying cues, i.e. nanotopography stiffness. Through independent variation stiffness topography, found that constitutes primary cue can override signals attenuate Specifically, restricts cytoskeletal remodeling-associated signaling, leads reduced This finding expands our understanding nanoscale be exploited in biomaterials design induce desirable