Systematical Evaluation of Mechanically Strong 3D Printed Diluted magnesium Doping Wollastonite Scaffolds on Osteogenic Capacity in Rabbit Calvarial Defects

• DOI: 10.1038/srep34029
• Publication Date: 2016-09-23T10:05:23Z
• Authors: Miao Sun; An Liu; Huifeng Shao; Xianyan Yang; Chiyuan Ma; Shigui Yan; Yanming Liu; Yong He; Zhongru Gou
• Keywords: Wollastonite; Bone tissue

Abstract Wollastonite (CaSiO3; CSi) ceramic is a promising bioactive material for bone defect repair due to slightly fast degradation of its porous constructs in vivo . In our previous strategy some key features CSi have been significantly improved by dilute magnesium doping regulating mechanical properties and biodegradation. Here we demonstrate that 6 ~ 14% Ca substituted Mg (CSi-Mgx, x = 6, 10, 14) can enhance the strength (>40 MPa) but not compromise biological performances 3D printed scaffolds with open porosity 60‒63%. The vitro cell culture tests indicated into was beneficial ALP activity high expression osteogenic marker genes MC3T3-E1 cells scaffolds. A good tissue regeneration response elastoplastic were determined after implantation rabbit calvarial defects 6‒12 weeks. Particularly, CSi-Mg10 CSi-Mg14 could new significant increase newly formed (18 22%) compared pure (~14%) at 12 weeks post-implantation. It reasonable consider that, therefore, such CSi-Mgx possessing excellent degradability are reconstruction thin-wall defects.