Key clinical beam parameters for nanoparticle-mediated radiation dose amplification

• DOI: 10.1038/srep34040
• Publication Date: 2016-09-23T10:02:56Z
• Authors: Alexandre Detappe; Sijumon Kunjachan; Pascal Drané; Shady Kotb; Marios Myronakis; Douglas E. Biancur; Thomas Ireland; Matthew Wagar; Francois Lux; Olivier Tillement; Ross Berbeco
• Keywords: External beam radiation; Linear energy transfer

As nanoparticle solutions move towards human clinical trials in radiation therapy, the influence of key beam parameters on therapeutic efficacy must be considered. In this study, we have investigated therapy delivery variables that may significantly affect nanoparticle-mediated dose amplification. We found a benefit for situations which increased proportion low energy photons incident beam. Most notably, "unflattened" photon beams from linear accelerator results improved outcomes relative to conventional "flat" beams. This is measured by significant DNA damage, tumor growth suppression, and overall improvement survival pancreatic model. These results, obtained setting, clearly demonstrate importance will impact amplification with nanoparticles.