In vitro and in vivo study of additive manufactured porous Ti6Al4V scaffolds for repairing bone defects

• DOI: 10.1038/srep34072
• Publication Date: 2016-09-26T10:59:02Z
• Authors: Guoyuan Li; Lei Wang; Wei Pan; Fei Yang; Wenbo Jiang; Xianbo Wu; Xiangdong Kong; Kerong Dai; Yongqiang Hao
• Keywords: Stress shielding

Metallic implants with a low effective modulus can provide early load-bearing and reduce stress shielding, which is favorable for increasing in vivo life-span. In this research, porous Ti6Al4V scaffolds three pore sizes (300~400, 400~500, 500~700 μm) were manufactured by Electron Beam Melting, an elastic range of 3.7 to 1.7 GPa. Cytocompatibility vitro osseointegration ability assessed. hBMSCs numbers increased on all over time. The group intended 300 400 μm was significantly higher than that the other two at days 5 7. This also had ALP activity day 7 osteogenic differentiation experiment. scaffold size implanted into 30-mm segmental defect goat metatarsus. evaluations indicated depth bone ingrowth time no implant dislocation occurred during Based its better cytocompatibility ingrowth, present data showed capability additive large defects.