Potentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis

• DOI: 10.1038/srep34157
• Publication Date: 2016-09-28T10:05:35Z
• Authors: Bin-bin Li; Dong-liang Li; Chao Chen; Bao-hai Liu; Chun-yan Xia; Han-jun Wu; Chao-qun Wu; Guo-qin Ji; Su Liu; Wu Ni; Ding-kang Yao; Zhi-yu Zeng; Da-gui Chen; Bao-dong Qin; Xuan Xin; Gang-li Yan; Dan Tang; Hui-min Liu; Jin He; Hongli Yan; Wei-Jian Zhu; Hong-yu Yu; Liang Zhu
• Keywords: 0301 basic medicine; 03 medical and health sciences; Article; 3. Good health

Abstract Early diagnosis of liver fibrosis is critical for early intervention and prognosis various chronic diseases. Conventional repeated histological assessment impractical due to the associated invasiveness. In current study, we evaluated circulating miR-185 as a potential biomarker predict initiation progression fibrosis. We found that was significantly up-regulated in blood specimens from patients with HBV-liver rats fibrosis, levels were correlated progression, but not different viral loads HBV-infected patients. observed collagen deposition regions during advanced differences facilitated discrimination between early-staged or advanced-staged healthy controls high specificity, sensitivity, likelihood ratio using receiver-operator characteristic analysis. targeted SREBF1, increased expression COL1A1 a-SMA genes are hallmarks Our data supported could be used biomarkers