Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

• DOI: 10.1038/srep34489
• Publication Date: 2016-09-28T09:33:15Z
• Authors: Miaomiao Zhang; Xingxing Zhang; Kaidi Xu; Qiaoyang Teng; Qinfang Liu; Xuesong Li; Jianmei Yang; Jianqing Xu; Hongjun Chen; Xiaoyan Zhang; Zejun Li
• Keywords: 0301 basic medicine; Epidemiology; Dynamics of Livestock Disease Transmission and Control; Life Sciences; Influenza A virus subtype H5N1; Avian influenza virus; FOS: Health sciences; Article; Virus; 3. Good health; Agricultural and Biological Sciences; 03 medical and health sciences; Infectious Diseases; Virology; Health Sciences; Medicine; Erratum; Influenza Virus Research and Epidemiology; Agronomy and Crop Science; Biology; Viral Hemorrhagic Fevers and Zoonotic Infections; Epidemiological Patterns

AbstractThree H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.