P[8] and P[4] Rotavirus Infection Associated with Secretor Phenotypes Among Children in South China

• DOI: 10.1038/srep34591
• Publication Date: 2016-10-06T09:36:59Z
• Authors: Xu-Fu Zhang; Yan Long; Ming Tan; Ting Zhang; Qiong Huang; Xi Jiang; Wen-Fang Tan; Jian-Dong Li; Gui-Fang Hu; Shixing Tang; Ying-Chun Dai
• Keywords: Male; Rotavirus; 0303 health sciences; Genotype; Infant; Article; Rotavirus Infections; 3. Good health; Feces; 03 medical and health sciences; Child, Preschool; Humans; Female; Child

Abstract Rotaviruses are known to recognize human histo-blood group antigens (HBGAs) as a host ligand that is believed play an important role in rotavirus susceptibility and range. In this study, paired fecal saliva samples collected from children with viral gastroenteritis, well serum the general population south China were studied evaluate potential association between infections HBGA phenotypes. Rotavirus was detected 75 (28%) of 266 P[8] rotaviruses found be predominant genotype. The phenotypes rotavirus-infected determined through their samples. Secretor statuses correlate risk infection all P[8]/P[4] infected secretors. Accordingly, recombinant VP8* proteins bound secretor individuals. Furthermore, correlation P[8]/P[4]-specific IgG Lewis has been among 206 Our study supported phenotypes, which would help further understanding range epidemiology.