Coronary artery calcium is associated with cortical thinning in cognitively normal individuals

• DOI: 10.1038/srep34722
• Publication Date: 2016-10-03T09:57:21Z
• Authors: Jin San Lee; Danbee Kang; Young Kyoung Jang; Hee Jin Kim; Duk L. Na; Hee Young Shin; Mira Kang; Jin-Ju Yang; Jong-Min Lee; Juyoun Lee; Yeo Jin Kim; Key-Chung Park; Eliseo Guallar; Sang Won Seo; Juhee Cho
• Keywords: Association (psychology)

Abstract To evaluate the association between coronary artery calcium (CAC) and cortical thickness in a large sample of cognitively normal individuals, with special emphasis determining if has regional brain specificity it is mediated by white matter hyperintensities (WMH). A total 512 participants were included this study. CAC scores assessed multi-detector computed tomography. Cortical was measured using surface-based method. Linear mixed models used to assess thickness. In fully adjusted models, increased associated thinning across several regions, which generally overlapped distribution default mode network. The significantly stronger moderate or severe WMH compared those none mild WMH, even though not WMH. adults, areas related cognitive function. This evident after adjusting for multiple disease risk factors suggesting that may be more closely Alzheimer’s Disease-type rather than cerebral small vessel disease.