Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification

• DOI: 10.1038/srep35613
• Publication Date: 2016-10-20T09:48:50Z
• Authors: Jian Yang; Jing Yang; Steven H. Liang; Yungen Xu; Anna Moore; Chongzhao Ran
• Keywords: Amyloid (mycology); Amyloid beta; Scavenger

Abstract In brains of Alzheimer’s disease (AD), reactive oxygen species (ROS) levels are significantly higher than that healthy brains. Evidence suggests that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Aβ) production, aggregation, plaque formation, microglia/immunological responses, inflammation, ROS production. this cycle, play central role, H 2 O is one the most important species. report, we have designed fluorescent imaging probe CRANAD-88, which capable cascade amplifying near infrared fluorescence (NIRF) signals at three upon interacting with in We demonstrated amplification was feasible vitro vivo . Remarkably, showed for first time, it to monitor changes concentrations before after treatment an scavenger. Our method opens new revenues investigate can be very instructive drug development.