Impact of sialic acids on the molecular dynamic of bi-antennary and tri-antennary glycans

• DOI: 10.1038/srep35666
• Publication Date: 2016-10-19T09:16:59Z
• Authors: Alexandre Guillot; Manuel Dauchez; Nicolas Belloy; Jessica Jonquet; Laurent Duca; Beatrice Romier; Pascal Maurice; Laurent Debelle; Laurent Martiny; Vincent Durlach; Stephanie Baud; Sebastien Blaise
• Keywords: Monosaccharide

Abstract Sialic acids (SA) are monosaccharides that can be located at the terminal position of glycan chains on a wide range proteins. The post-translational modifications, such as N-glycan chains, fundamental to protein functions. Indeed, hydrolysis SA by specific enzymes neuraminidases lead drastic modifications behavior. However, relationship between desialylation and possible alterations receptor function remains unexplored. Thus, aim present study is establish impact removal from their conformational We therefore undertook an in silico investigation using molecular dynamics predict structure isolated chain. performed, for first time, 3 independent 500 ns simulations bi-antennary tri-antennary displaying or lacking SA. show alters both preferential conformation flexibility This suggests behavior induced presence absence may explain changes function.