Effectiveness evaluation of organized screening for esophageal cancer: a case-control study in Linzhou city, China

• DOI: 10.1038/srep35707
• Publication Date: 2016-10-19T09:32:46Z
• Authors: Qiong Chen; Liang Yu; Changqing Hao; Jinwu Wang; Shuzheng Liu; Meng Zhang; Shaokai Zhang; Lanwei Guo; Peiliang Quan; Patrick Germain; Yawei Zhang; Xibin Sun
• Keywords: Conditional logistic regression; Cancer screening

In China, esophageal cancer has remained a large burden, and endoscopic screening is expected to reduce mortality. Therefore, population-based case-control study was conducted evaluate the effect of screening. Cases were defined as individuals who had died cancer, controls residents from same area (three per case) not matched by gender birth year. The exposure status (whether cases ever attended or not) acquired inspecting well documented records. A conditional logistic regression model used estimate odds ratios (OR) their 95% confidence intervals (95% CI). There 253 759 controls. reduction in risk mortality 47% (OR: 0.53, CI: 0.37-0.77). Compared with never-screened subjects, ORs for screened subjects within 36 48 months before reference date 0.59(0.39-0.89) 0.59(0.40-0.87); 50-59 year old 0.48(0.28-0.85). results suggest due screening, which may have significant implications especially rural areas.