Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies

• DOI: 10.1038/srep36048
• Publication Date: 2016-11-03T10:23:35Z
• Authors: Nan Wu; Yu-Long Song; Bei Wang; Xiang-Yang Zhang; Xu-Jie Zhang; Ya-Li Wang; Ying-Yin Cheng; Dan-Dan Chen; Xiao-Qin Xia; Yi-Shan Lu; Yong-An Zhang
• Keywords: Proteome; Homeostasis

Abstract The gut-associated lymphoid tissue, connected with liver via bile and blood, constructs a local immune environment of both defense tolerance. gut-liver immunity has been well-studied in mammals, yet fish remains largely unknown, even though enteritis as well gallbladder syndrome emerged limitation aquaculture. In this study, we performed integrative bioinformatic analysis for transcriptomic (gut liver) proteomic (intestinal mucus bile) data, healthy infected tilapias. We found more categories transcripts gut than liver, adaptive meanwhile innate liver. Interestingly reduced differential between upon inflammation were also revealed. addition, proteins intestinal identified. And probably providing effectors to was deduced. Specifically, many key or demonstrated. Accordingly, proposed hypothesized profile immunity, during either homeostasis inflammation. Current data suggested that may collaborate immunologically while keep using own strategies, including potential unique mechanisms.