ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer

• DOI: 10.1038/srep36387
• Publication Date: 2016-11-03T10:14:22Z
• Authors: Lídia Cedó; Annabel García-León; Lucía Baila-Rueda; David Santos; Victor Grijalva; Melanie Raquel Ma...; José M. Carbó; Jari Metso; Laura López-Vilaró; Antonio Zorzano; Annabel F. Valledor; Ana Cenarro; Matti Jauhiainen; Enrique Lerma; Alan M. Fogelman; Srinivasa T. Reddy; Joan Carles Escol...; Francisco Blanco-...
• Keywords: Hiperlipoproteïnes; Cell Survival; Lipoproteins; Oncology and Carcinogenesis; 610; Antineoplastic Agents; Breast Neoplasms; Mice, Transgenic; Cardiovascular; Transgenic; Article; LDL; Càncer de mama; Mice; 03 medical and health sciences; Breast cancer; 616; Breast Cancer; 2.1 Biological and endogenous factors; Transgenic mice; Animals; Humans; Aetiology; Cancer; Cell Proliferation; High density lipoproteins; 0303 health sciences; Biomedical and Clinical Sciences; Apolipoprotein A-I; Molecular Mimicry; Atherosclerosis; Xenograft Model Antitumor Assays; 3. Good health; Lipoproteins, LDL; MCF-7 Cells; Female; Pèptids; Peptides; Ratolins transgènics

Abstract Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies reported contradictory results regard to the relationship between apolipoprotein (apo) A-I and cancer. We aimed determine effects human apoA-I overexpression administration specific mimetic peptide (D-4F) on tumour progression by using mammary virus-polyoma middle T-antigen transgenic (PyMT) mice as a model inherited Expression in did not affect onset growth PyMT mice, despite an increase HDLc level. In contrast, D-4F treatment significantly increased latency inhibited development tumours. The were independent 27-hydroxycholesterol. However, reduced plasma oxidized low-density (oxLDL) prevented oxLDL-mediated proliferative response adenocarcinoma MCF-7 cells. conclusion, our study shows that D-4F, apoA-I-containing HDL, hinders association higher protection against LDL oxidative modification.