Gata4 is critical to maintain gut barrier function and mucosal integrity following epithelial injury

• DOI: 10.1038/srep36776
• Publication Date: 2016-11-09T10:06:39Z
• Authors: David Lepage; Élise Bélanger; Christine Jones; Sarah Tremblay; Joannie M. Allaire; Joannie Bruneau; Claude Asselin; Nathalie Perreault; Alfredo Menendez; Fernand-Pierre Ge...; Francois Boudreau
• Keywords: Barrier function; GATA4

Abstract The intestinal epithelial barrier is critical to limit potential harmful consequences from exposure deleterious luminal contents on the organism. Although this functionally important along entire gut, specific regional regulatory mechanisms involved in maintenance of are poorly defined. Herein, we identified Gata4 as a crucial regulator integrity mouse proximal epithelium. Conditional deletion intestine led drastic increase claudin-2 expression that was associated with an gut permeability without causing overt spontaneous inflammation. Administration indomethacin, non-steroidal anti-inflammatory drug (NSAID) causes enteritis, rapid and restricted small injuries mutant mice opposed control mice. Comparative analysis gene transcript profiles indomethacin-challenged defects cell survival, inflammatory recruitment tissue repair mechanisms. Altogether, these observations identify novel transcription factor implicated mucosal after injury.