Soluble γc cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus

• DOI: 10.1038/srep36962
• Publication Date: 2016-11-11T10:02:09Z
• Authors: Joo-Young Park; Yuna Jo; Eunhee Ko; Megan A. Luckey; Yoo Kyoung Park; Se-Ho Park; Jung-Hyun Park; Changwan Hong
• Keywords: Thymocyte

Abstract The soluble γc protein (sγc) is a naturally occurring splice isoform of the cytokine receptor that produced by activated T cells and inhibits signaling. Here we show sγc expression also highly upregulated in immature CD4 + CD8 thymocytes but then downregulated mature thymocytes. These results indicate developmentally controlled mechanism for suggest potential role regulating cell development thymus. Indeed, overexpression resulted significantly reduced thymocyte numbers diminished expansion thymocytes, concordant to its suppressing signaling IL-7, critical early thymopoiesis. Notably, impaired generation i NKT cells, resulting percentages requires IL-15, found interfered with IL-15 suppress Thus, represents new control availability during constrains production specifically