SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease

• DOI: 10.1038/srep37351
• Publication Date: 2016-11-17T10:58:46Z
• Authors: Yuhan Liu; Fudong Yu; Yan Han; Qing Li; Zhujun Cao; Xiaogang Xiang; Shaowen Jiang; Xiaolin Wang; Jie Lu; Rongtao Lai; Hui Wang; Wei Cai; Shisan Bao; Qing Xie
• Keywords: Lipid droplet

Abstract Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes. The role of SENP3 metabolism, particularly NAFLD, unclear. Our results showed that hepatic was up-regulated NAFLD patients and an animal model vivo after loading hepatocytes with free acids (FFA) vitro . Intracellular determined silenced or overexpressed with/without FFA Confirming a for SENP3, gene silencing associated amelioration overexpression enhancement accumulation. related genes were using RNA-Seq. Eleven unique closely metabolism generated bioinformatics. Three selected ( apoe, a2m tnfrsf11b ) verified , showing regulated stimulation. Intrahepatic circulating APOE, A2M TNFRSF11B elevated compared controls. These data demonstrate the important during development via downstream genes, which may be useful information NAFLD. precise will investigated liver-specific conditional knockout mice future studies.