Baseline neutrophil–lymphocyte ratio is associated with baseline and subsequent presence of brain metastases in advanced non-small-cell lung cancer

• DOI: 10.1038/srep38585
• Publication Date: 2016-12-07T10:43:36Z
• Authors: Young Wha Koh; Jin-Hyuk Choi; Mi Sun Ahn; Yong Won Choi; Hyun Woo Lee
• Keywords: Adult; Aged, 80 and over; Lung Neoplasms; Brain Neoplasms; Neutrophils; Middle Aged; Prognosis; Magnetic Resonance Imaging; Article; 3. Good health; Leukocyte Count; 03 medical and health sciences; 0302 clinical medicine; ROC Curve; Carcinoma, Non-Small-Cell Lung; Humans; Lymphocytes; Tomography, X-Ray Computed; Biomarkers; Aged; Neoplasm Staging

Abstract We examined the predictive value of neutrophil–lymphocyte ratio (NLR) by examining their association with baseline presence and subsequent development brain metastases in patients stage IV non-small cell lung cancer (NSCLC). NLR for metastasis 260 NSCLC. Logistic regression models competing risk analysis were used to determine metastases. Multivariate reveals that high (≥4.95) had significantly more at diagnosis than those low (Odds Ratio = 2.59, P 0.01). In who no metastasis, risks revealed showed higher cumulative incidence metastases, compared ( 0.017). A was associated or particularly group adenocarcinoma 0.013 0.044, respectively). Furthermore, an increase during treatment 0.004). The is independent factor