In vivo response of AZ31 alloy as biliary stents: a 6 months evaluation in rabbits

• DOI: 10.1038/srep40184
• Publication Date: 2017-01-13T10:31:06Z
• Authors: Yang Liu; Shengmin Zheng; Nan Li; Huahu Guo; Yufeng Zheng; Jirun Peng
• Keywords: Common Bile Duct; Inflammation; Time Factors; Histocytochemistry; 02 engineering and technology; Article; 3. Good health; Biliary Tract Surgical Procedures; Alloys; Animals; Stents; Rabbits; 0210 nano-technology; Blood Chemical Analysis

AbstractMg-based metallic materials have been making continuing progress as vascular stents. However, the research of Mg-based materials as non-vascular stents is still at its primary stage. AZ31 stents hereby were implanted into the common bile duct of rabbits for 6 months. The results revealed an existence of 93.82 ± 1.36% and 30.89 ± 2.46% of the original volume after 1 and 3 month, respectively. Whole blood tests indicated an inflammation decreasing to normal level after 3 month implantation. A benign host response was observed viaH&Estaining. Nonuniform corrosion at the two ends of the stents was observed and considered the results of flow or local inflammation. Moreover, the application of Mg-based materials for different stenting treatment were reviewed and compared. Esophagus was hypothesized most destructive, whilst blood vessel and bile duct considered similar and less destructive. Trachea and nasal cavity were thought to be mildest.