Evidence of Microvascular Changes in the Retina following Kawasaki Disease

Adult Male retina Adolescent 610 Mucocutaneous Lymph Node Syndrome Article Retina 618 Young Adult 03 medical and health sciences 0302 clinical medicine male mucocutaneous lymph node syndrome Risk Factors 616 Humans human Child child adult Retinal Vessels case control study 16. Peace & justice 3. Good health female retina blood vessel risk factor adolescent Case-Control Studies young adult pathology Female
DOI: 10.1038/srep40513 Publication Date: 2017-01-17T12:47:07Z
ABSTRACT
Abstract It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and associated traditional risk factors events. aim of this study was to investigate microvascular parameters two populations patients previous KD control participants. We performed case-control studies 116 (57 59 participants) Australian 156 (78 78 Singaporean individuals, at least years since their acute illness. Standardised photographs were graded by trained technicians using a semi-automated software, which quantifies (calibre, branching angle, fractal dimensions, tortuosity). Retinal venules 9.67 μm (95% CI 4.87 14.51, p < 0.001) larger than participants following correction for factors. An incremental increase size those coronary artery abnormalities observed. There limited evidence that compared (7.34 μm, 95% 1.30 15.99, = 0.10). Differences particularly evident patients. Larger may reflect chronic inflammation endothelial dysfunction, are adults.
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