Evidence of Microvascular Changes in the Retina following Kawasaki Disease

• DOI: 10.1038/srep40513
• Publication Date: 2017-01-17T12:47:07Z
• Authors: Katherine Y. H. Chen; David P. Burgner; Tien Y. Wong; Seang Mei Saw; Swee Chye Quek; Audrey Y. C. Pang; Seo Wei Leo; Inez B. Wong; Diana Zannino; Nigel Curtis; Michael Cheung; Carol Y. Cheung; Terence C. W. Lim
• Keywords: Adult; Male; retina; Adolescent; 610; Mucocutaneous Lymph Node Syndrome; Article; Retina; 618; Young Adult; 03 medical and health sciences; 0302 clinical medicine; male; mucocutaneous lymph node syndrome; Risk Factors; 616; Humans; human; Child; child; adult; Retinal Vessels; case control study; 16. Peace & justice; 3. Good health; female; retina blood vessel; risk factor; adolescent; Case-Control Studies; young adult; pathology; Female

Abstract It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and associated traditional risk factors events. aim of this study was to investigate microvascular parameters two populations patients previous KD control participants. We performed case-control studies 116 (57 59 participants) Australian 156 (78 78 Singaporean individuals, at least years since their acute illness. Standardised photographs were graded by trained technicians using a semi-automated software, which quantifies (calibre, branching angle, fractal dimensions, tortuosity). Retinal venules 9.67 μm (95% CI 4.87 14.51, p < 0.001) larger than participants following correction for factors. An incremental increase size those coronary artery abnormalities observed. There limited evidence that compared (7.34 μm, 95% 1.30 15.99, = 0.10). Differences particularly evident patients. Larger may reflect chronic inflammation endothelial dysfunction, are adults.