Evidence of Microvascular Changes in the Retina following Kawasaki Disease
Adult
Male
retina
Adolescent
610
Mucocutaneous Lymph Node Syndrome
Article
Retina
618
Young Adult
03 medical and health sciences
0302 clinical medicine
male
mucocutaneous lymph node syndrome
Risk Factors
616
Humans
human
Child
child
adult
Retinal Vessels
case control study
16. Peace & justice
3. Good health
female
retina blood vessel
risk factor
adolescent
Case-Control Studies
young adult
pathology
Female
DOI:
10.1038/srep40513
Publication Date:
2017-01-17T12:47:07Z
AUTHORS (13)
ABSTRACT
Abstract It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and associated traditional risk factors events. aim of this study was to investigate microvascular parameters two populations patients previous KD control participants. We performed case-control studies 116 (57 59 participants) Australian 156 (78 78 Singaporean individuals, at least years since their acute illness. Standardised photographs were graded by trained technicians using a semi-automated software, which quantifies (calibre, branching angle, fractal dimensions, tortuosity). Retinal venules 9.67 μm (95% CI 4.87 14.51, p < 0.001) larger than participants following correction for factors. An incremental increase size those coronary artery abnormalities observed. There limited evidence that compared (7.34 μm, 95% 1.30 15.99, = 0.10). Differences particularly evident patients. Larger may reflect chronic inflammation endothelial dysfunction, are adults.
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