Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study

• DOI: 10.1038/srep41516
• Publication Date: 2017-01-31T10:57:23Z
• Authors: Mónica García-Álv...; Juan Berenguer; María A. Jiménez-...; Daniel Pineda-Tenor; Teresa Aldámiz-Ec...; Francisco Tejerina; Cristina Diez; Sonia Vázquez-Morón; Salvador Resino
• Keywords: Liver disease; Hepatitis C

Abstract The mechanisms involved in the chronic hepatitis C progression are incompletely understood. aim was to analyze association between 2 ′ 5 oligoadenylate synthetase 1,2 and 3 (OAS1-3 ) myxovirus resistance proteins 1 (Mx1 polymorphisms severity of liver disease human immunodeficiency virus (HIV)/hepatitis (HCV) coinfected patients. We performed a cross-sectional study 219 patients that underwent biopsy. DNA genotyping for Mx1 (rs469390), OAS1 (rs2285934), OAS2 (rs1293762) OAS3 (rs2010604) by using GoldenGate assay. outcome variables ion biopsy were: (i) significant fibrosis (F ≥ 2); (ii) moderate activity grade (A 2). Additive model inheritance genetic test used. likelihood having 2) lower carrying rs1293762 A allele [adjusted odds ratio (aOR) = 0.51; p 0.040]. Besides, higher rs464397 (aOR 1.63; 0.028) rs469390 G 1.97; 0.005), while it rs2285934 0.64; 0.039) 0.41; 0.009). In conclusion, OAS1-2 were associated with HIV/HCV-coinfected patients, suggesting role hepatic fibrosis.