DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences

• DOI: 10.1038/srep41580
• Publication Date: 2017-01-30T11:40:37Z
• Authors: S. Musilli; N. Nicolas; Z. El Ali; P. Orellana-Moreno; C. Grand; K. Tack; S. Kerdine-Römer; J. M. Bertho
• Keywords: Senescence

Abstract 90 Sr is one of the radionuclides released after nuclear accidents that can significantly impact human health in long term. accumulates mostly bones exposed populations. Previous research has shown exposure induces changes bone physiology both humans and mice. We hypothesize that, due to its close location with marrow stromal cells (BMSCs), could induce functional damage may explain these biological effects chronic Sr. The aim this work was verify hypothesis through use an vitro model MS5 cell lines 1 10 kBq.mL −1 Results indicated a 30-minute induced double strand breaks DNA, followed by DNA repair, senescence differentiation. After 7 days exposure, showed decreased ability proliferate, cytokine expression, their support hematopoietic progenitor proliferation These results demonstrate low concentration BMSCs turn observed following exposure.