Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array

• DOI: 10.1038/srep41970
• Publication Date: 2017-02-07T10:05:33Z
• Authors: M. Toi; Y. Asao; Y. Matsumoto; H. Sekiguchi; A. Yoshikawa; M. Takada; M. Kataoka; T. Endo; N. Kawaguchi-Sakita; M. Kawashima; E. Fakhrejahani; S. Kanao; I. Yamaga; Y. Nakayama; M. Tokiwa; M. Torii; T. Yagi; T. Sakurai; K. Togashi; T. Shiina
• Keywords: Adult; Aged, 80 and over; Carcinoma, Ductal, Breast; Breast Neoplasms; Middle Aged; Magnetic Resonance Imaging; 01 natural sciences; Article; 3. Good health; Photoacoustic Techniques; Young Adult; 0103 physical sciences; Image Processing, Computer-Assisted; Blood Vessels; Humans; Female; Breast; Algorithms; Aged

Abstract Noninvasive measurement of the distribution and oxygenation state hemoglobin (Hb) inside tissue is strongly required to analyze tumor-associated vasculatures. We developed a photoacoustic imaging (PAI) system with hemispherical-shaped detector array (HDA). Here, we show that PAI HDA revealed finer vasculature, more detailed blood-vessel branching structures, morphological vessel characteristics compared MRI by use breast shape deformation their fused image. Morphologically abnormal peritumoral blood features, including centripetal signals disruption or narrowing signals, were observed intratumoral detected in cancer tissues as result clinical study 22 malignant cases. Interestingly, it was also possible anticancer treatment-driven changes vascular features function, such improvement perfusion relevant intravascular saturation oxygen. This indicated appears be promising tool for noninvasive analysis human vessels may contribute improve diagnosis.