Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder

• DOI: 10.1038/srep42621
• Publication Date: 2017-02-15T10:27:31Z
• Authors: Kyu-Man Han; Eunsoo Won; Youngbo Sim; June Kang; Changsu Han; Yong-Ku Kim; Seung-Hyun Kim; Sook-Haeng Joe; Min-Soo Lee; Woo-Suk Tae; Byung-Joo Ham
• Keywords: FKBP5; Supramarginal gyrus

Abstract A single nucleotide polymorphism of rs1360780 in the FKBP5 gene is associated with a predisposition to developing major depressive disorder (MDD). We investigated interactive effects allelic variants, DNA methylation, and diagnosis MDD on structural changes entire brain. One hundred fourteen patients eighty-eight healthy controls underwent T1-weighted magnetic resonance imaging genotyping, including methylation intron 7. analyzed volume cortical subcortical regions thickness using FreeSurfer. Significant genotype-by-diagnosis interactions were observed for volumes left pars triangularis, supramarginal gyrus, superior parietal lobule, right frontomarginal, posterior midcingulate gyrus. The T allele was significant reductions these brain only group except showed positive correlation transverse frontopolar gyrus C homozygote group. Our findings suggest that its epigenetic could have influence morphologic several involved emotion regulation, this process may be development MDD.