Complement component 5 promotes lethal thrombosis

• DOI: 10.1038/srep42714
• Publication Date: 2017-02-16T10:11:21Z
• Authors: Tomohiro Mizuno; Kengo Yoshioka; Masashi Mizuno; Mie Shimizu; Fumihiko Nagano; Tomoyuki Okuda; Naotake Tsuboi; Shoichi Maruyama; Tadashi Nagamatsu; Masaki Imai
• Keywords: Blood Platelets; Male; 0303 health sciences; Platelet Aggregation; Complement C5; Thrombosis; Article; 3. Good health; Histones; Mice; 03 medical and health sciences; Mice, Inbred DBA; Leukocytes; Animals; Liver Failure

Abstract Extracellular histones promote platelet aggregation and thrombosis; this is followed by induction of coagulation disorder, which results in exhaustion factors. Complement component 5 (C5) known to be associated with system activation. To date, the pathological mechanism underlying liver injury has remained unclear. Here, we investigated whether C5 promotes histone-induced lethal thrombosis. C5-sufficient C5-deficient mice received single tail vein injections purified, unfractionated obtained from calf thymus (45–75 μg/g). Subsequently, were monitored for survival up 72 h. Based on data, 45 μg/g dose was used analysis blood cell count, function, ability, promotion platelet/leukocyte aggregate (PLA) production extracellular histones. protected thrombosis had milder thrombocytopenia, consumptive coagulopathy, embolism lower PLA than mice. These indicate that disorders, production, embolism-induced injury. In conclusion,