CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis

• DOI: 10.1038/srep43310
• Publication Date: 2017-03-07T10:35:26Z
• Authors: Yue Sun; Jie Zhang; Tianhang Zhai; Huidan Li; Haichuan Li; Rongfen Huo; Baihua Shen; Beiqing Wang; Xiangdong Chen; Ningli Li; Jialin Teng
• Keywords: CYR61

Abstract CCN1, an extracellular protein also known as cysteine-rich 61 (Cyr61), is a novel pro-inflammatory factor involved in the pathogenesis of rheumatoid arthritis. As inflammatory disease, psoriasis characterized by keratinocyte activation-induced epidermal hyperplasia and cytokine-mediated inflammation. We demonstrated our previous study that CCN1 promoted activation psoriasis. However, role regulating inflammation still unknown. Here, we showed increased cytokine IL-1β production keratinocytes. Furthermore, endogenous ATP caspase-1 were required for mature stimulated After binding to receptor integrin α6β1, activated downstream p38 MAPK signaling pathway, thus inducing expression IL-1β. In addition, inhibited function mouse models psoriasis, decreased was observed vivo . Overall, via signaling, indicating