Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration

• DOI: 10.1038/srep43926
• Publication Date: 2017-03-07T10:41:36Z
• Authors: Di Tang; Tiantian Yan; Junhui Zhang; Xupin Jiang; Dongxia Zhang; Yuesheng Huang
• Keywords: Hypoxia

Oxygen tension is an important micro-environmental factor that affects epidermal development and function. After injury, high oxygen consumption vascular injury result in partial hypoxia. However, whether hypoxia benefits or hurts wound healing remains controversial. In this study, a tissue monitor was used to detect the spatial temporal distribution of burn wounds. vitro, we demonstrate promoted expression integrin β1 migration keratinocytes. Furthermore, hypoxia-induced slowed by Notch1 ligands siRNA against ITGB1 (integrin β1). Our findings suggest may be oxygen-sensitive molecule promotes keratinocyte during signaling involved process.