Anordrin Eliminates Tamoxifen Side Effects without Changing Its Antitumor Activity

0301 basic medicine Mice, Inbred ICR Norandrostanes Antineoplastic Agents, Hormonal Mice, Nude Contraceptives, Oral, Synthetic Article Endometrial Neoplasms 3. Good health Tamoxifen 03 medical and health sciences Treatment Outcome Non-alcoholic Fatty Liver Disease Cell Line, Tumor Animals Heterografts Humans Female Neoplasm Transplantation
DOI: 10.1038/srep43940 Publication Date: 2017-03-07T10:41:59Z
ABSTRACT
Abstract Tamoxifen is administered for estrogen receptor positive (ER + ) breast cancers, but it can induce uterine endometrial cancer and non-alcoholic fatty liver disease (NAFLD). Importantly, ten years of tamoxifen treatment has greater protective effect against ER than five such treatment. was also approved by the FDA as a chemopreventive agent those deemed at high risk development cancer. The side effects are substantial concern because these extended methods administration. In this study, we found that anordrin, marketed an antifertility medicine in China, inhibited tamoxifen-induced epithelial cell mitosis NAFLD mouse uterus anti-estrogenic estrogenic agent, respectively. Additionally, compared with tamoxifen, anordiol, active metabolite weakly bound to ligand binding domain ER-α. Anordrin did not regulate classic nuclear pathway; thus, affect anti-tumor activity nude mice. Taken together, data suggested anordrin could eliminate without affecting its activity.
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