Treatment of rabbit growth plate injuries with oriented ECM scaffold and autologous BMSCs

• DOI: 10.1038/srep44140
• Publication Date: 2017-03-07T10:52:54Z
• Authors: Wenchao Li; Ruijiang Xu; Jiangxiang Huang; Xing Bao; Bin Zhao
• Keywords: 0303 health sciences; 03 medical and health sciences; Tibia; Tissue Scaffolds; Animals; Salter-Harris Fractures; Rabbits; Autografts; Article; Bone Marrow Transplantation; Extracellular Matrix

Abstract Tissue-engineered technology has provided a promising method for the repair of growth plate injuries using biocompatible and biodegradable scaffolds appropriate cells. The aim this study was to fabricate oriented ECM imitate material structure natural investigate whether BMSCs in scaffold could prevent formation bone bridges an injured plate. We developed natural, acellular derived from fabricated new freeze-drying by cross-linking microfilaments From histological examination, contained most components including GAG collagen II without cell DNA fragments, SEM revealed that had uniform aperture transverse plane columnar length plane. Cytotoxicity testing with MTT showed no cytotoxic effect extracts on BMSCs. Autogenous promoted regeneration neogenetic when repairing reduce angular deformity discrepancy proximal tibia rabbits. well-characterized ECM-derived shows potential plates young