The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy

• DOI: 10.1038/srep44430
• Publication Date: 2017-03-15T10:15:04Z
• Authors: Stanislovas S. Ja...; Irina B. Pevzner; Nadezda V. Andria...; Ljubava D. Zorova; Vasily A. Popkov; Denis N. Silachev; Nataliya G. Kolosova; Egor Y. Plotnikov; Dmitry B. Zorov
• Keywords: Ischemic Preconditioning; Renal ischemia; PINK1

In young rats, ischemic preconditioning (IPC), which consists of 4 cycles ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However,old rats lost their ability to protect the IPC. A similar aged phenotype was demonstrated in 6-month-old OXYS having signs premature aging. old levels acetylated nuclear proteins were higher than however, unlike acetylation further increased after contrast Wistar age-matched no increase lysosome abundance LC3 content ischemia/reperfusion. The also lower OXYS, even under basal conditions, mitochondrial PINK1 ubiquitin higher, suggesting impaired mitophagy. mitochondria from contained a population with diminished membrane potential this fraction expanded Apparently, oxidative changes aging result appearance malfunctioning renal due low efficiency autophagy. Elevated protein might be hallmark is associated decreased autophagy, accumulation dysfunctional mitochondria, loss protection against