HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma

Mesothelioma Glycosylation Lung Neoplasms Mesothelioma, Malignant Antibodies, Monoclonal Membrane Proteins Sensitivity and Specificity Article 3. Good health 03 medical and health sciences 0302 clinical medicine Cell Line, Tumor Biomarkers, Tumor Humans Cell Proliferation
DOI: 10.1038/srep45768 Publication Date: 2017-03-31T14:34:05Z
ABSTRACT
Abstract The absence of highly specific markers for malignant mesothelioma (MM) has served an obstacle its diagnosis and development molecular-targeting therapy against MM. Here, we show that a novel mucin-like membrane protein, sialylated protein HEG homolog 1 (HEG1), is marker A monoclonal antibody HEG1, SKM9-2, can detect even sarcomatoid desmoplastic specificity sensitivity SKM9-2 to MM reached 99% 92%, respectively; this did not react with normal tissues. This accurate discrimination by was due the recognition O -linked glycan HEG1 peptide. We also found gene silencing significantly suppressed survival proliferation cells; result suggests may be worthwhile target function-inhibition drugs. Taken together, our results indicate useful as diagnostic therapeutic
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