HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma
Mesothelioma
Glycosylation
Lung Neoplasms
Mesothelioma, Malignant
Antibodies, Monoclonal
Membrane Proteins
Sensitivity and Specificity
Article
3. Good health
03 medical and health sciences
0302 clinical medicine
Cell Line, Tumor
Biomarkers, Tumor
Humans
Cell Proliferation
DOI:
10.1038/srep45768
Publication Date:
2017-03-31T14:34:05Z
AUTHORS (22)
ABSTRACT
Abstract The absence of highly specific markers for malignant mesothelioma (MM) has served an obstacle its diagnosis and development molecular-targeting therapy against MM. Here, we show that a novel mucin-like membrane protein, sialylated protein HEG homolog 1 (HEG1), is marker A monoclonal antibody HEG1, SKM9-2, can detect even sarcomatoid desmoplastic specificity sensitivity SKM9-2 to MM reached 99% 92%, respectively; this did not react with normal tissues. This accurate discrimination by was due the recognition O -linked glycan HEG1 peptide. We also found gene silencing significantly suppressed survival proliferation cells; result suggests may be worthwhile target function-inhibition drugs. Taken together, our results indicate useful as diagnostic therapeutic
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (43)
CITATIONS (53)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....