Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis

• DOI: 10.1038/srep45952
• Publication Date: 2017-04-06T12:55:01Z
• Authors: Shi-Yao Wei; Yu-Xiao Wang; Qing-Fang Zhang; Shi-Lei Zhao; Tian-Tian Diao; Jian-Si Li; Wen-Rui Qi; Yi-Xin He; Xin-Yu Guo; Man-Zhu Zhang; Jian-Yu Chen; Xiao-Ting Wang; Qiu-Ju Wei; Yu Wang; Bing Li
• Keywords: Male; 0301 basic medicine; Rats, Inbred Dahl; Podocytes; Blood Pressure; Kidney; Fibrosis; Article; Capillaries; 3. Good health; 03 medical and health sciences; Hydrochlorothiazide; Kidney Tubules; Wnt4 Protein; Hypertension; Animals; Kidney Diseases; Sodium Chloride, Dietary; Antihypertensive Agents

Abstract Salt-sensitive hypertension (SSHT) leads to kidney interstitial fibrosis. However, the potential mechanisms leading renal fibrosis have not been well investigated. In present study, Dahl salt-sensitive (DS) rats were divided into three groups: normal salt diet (DSN), high (DSH) and treated with hydrochlorothiazide (HCTZ) (DSH + HCTZ). A significant increase in systolic blood pressure (SBP) was observed 3 weeks after initiating diet, marked histological alterations DSH rats. showed obvious podocyte injury, peritubular capillary (PTC) loss, macrophage infiltration, changes apoptosis cell proliferation. Moreover, Wnt/β-catenin signaling significantly activated HCTZ administration attenuated these decreased SBP. addition, increased urinary Wnt4 expression detected time closely correlated histopathological alterations. Furthermore, also confirmed by clinical study. conclusion, study provides novel insight related PTC infiltration SSHT-induced injury Therefore, multi-target therapeutic strategies may be most effective preventing pathological processes. a noninvasive biomarker for monitoring hypertension.