Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese

• DOI: 10.1038/srep46490
• Publication Date: 2017-04-21T09:15:23Z
• Authors: Ying Zhang; Yuanfeng Li; Miantao Wu; Pengbo Cao; Xiaomin Liu; Qian Ren; Yun Zhai; Bobo Xie; Yanling Hu; Zhibin Hu; Jinxin Bei; Jie Ping; Xinyi Liu; Yinghua Yu; Bingqian Guo; Hui Lu; Guanjun Liu; Haitao Zhang; Ying Cui; Zengnan Mo; Hongbing Shen; Yi-Xin Zeng; Fuchu He; Hongxing Zhang; Gangqiao Zhou
• Keywords: Genome-wide Association Study; Genetic Association; SNP

Abstract The sodium taurocholate cotransporting polypeptide (NTCP) encoded by SLC10A1 was recently demonstrated to be a functional receptor for hepatitis B virus (HBV). role of polymorphisms, particularly the Ser267Phe variant (rs2296651) in exon 4, has been frequently investigated regard risk persistent HBV infection. However, these investigations have generated conflicting results. To examine whether common genetic variation at locus is associated with infection, haplotype-tagging and imputed single nucleotide polymorphisms (SNPs) were assessed two case-control sample sets, totally including 2,550 cases (persistently infected subjects, PIs) 2,124 controls (spontaneously recovered SRs) Southern Chinese ancestry. test rare or subpolymorphic variants are disease risk, gene’s exons 244 sequenced. Overall, we found neither SNPs nor haplotypes showed significant association sets. Furthermore, no associations copy number covering observed. Finally, expression quantitative trait analyses revealed that potentially affecting also associations. We conclude not likely major factor infection among Chinese.