Spatiotemporally and Sequentially-Controlled Drug Release from Polymer Gatekeeper–Hollow Silica Nanoparticles

• DOI: 10.1038/srep46540
• Publication Date: 2017-04-24T09:37:47Z
• Authors: L. Palanikumar; M. T. Jeena; Kibeom Kim; Jun Yong Oh; Chaekyu Kim; Myoung-Hwan Park; Ja-Hyoung Ryu
• Keywords: Moiety; Internalization; Anticancer drug

Abstract Combination chemotherapy has become the primary strategy against cancer multidrug resistance; however, accomplishing optimal pharmacokinetic delivery of multiple drugs is still challenging. Herein, we report a sequential combination drug exploiting pH-triggerable and redox switch to release cargos from hollow silica nanoparticles in spatiotemporal manner. This versatile system further enables large loading efficiency for both hydrophobic hydrophilic inside nanoparticles, followed by self-crosslinking with disulfide diisopropylamine-functionalized polymers. In acidic tumour environments, positive charge generated protonation diisopropylamine moiety facilitated cellular uptake particles. Upon internalization, endosomal pH condition intracellular glutathione regulated time-dependent manner, providing promising therapeutic approach overcoming resistance during treatment.