Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

• DOI: 10.1038/tp.2015.214
• Publication Date: 2016-01-19T17:02:32Z
• Authors: J V Sanchez-Mut; H Heyn; E Vidal; S Moran; S Sayols; R Delgado-Morales; M D Schultz; B Ansoleaga; P Garcia-Esparcia; M Pons-Espinal; M M de Lagran; J Dopazo; A Rabano; J Avila; M Dierssen; I Lott; I Ferrer; J R Ecker; M Esteller
• Keywords: Epigenomics; CpG site

Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, those affecting DNA methylation, might also exist. studied samples were gray matter from prefrontal cortex control disease-associated cases. We performed methylation analyses Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease Alzheimer-like profile associated Down's syndrome samples. landscapes obtained that diseases share aberrant CpG shifts targeting a defined gene set. Our findings suggest have pathogenetic mechanisms subsequently evolve into different clinical entities. identified changes can be used biomarkers potential new targets for development therapies.