Cytokine production capacity in depression and anxiety

• DOI: 10.1038/tp.2016.92
• Publication Date: 2016-05-31T16:36:12Z
• Authors: N Vogelzangs; P de Jonge; J H Smit; S Bahn; B W Penninx
• Keywords: Beck Anxiety Inventory; Depression; Basal (medicine)

Abstract Recent studies have suggested that immune function may be dysregulated in persons with depressive and anxiety disorders. Few examined the expression of cytokines response to ex vivo stimulation blood by lipopolysaccharide (LPS) study innate production capacity depression anxiety. To investigate this, baseline data from Netherlands Study Depression Anxiety (NESDA) were used, including (18–65 years; 66% women) current (that is, past month; N =591) or remitted ( =354) DSM-IV disorders healthy controls =297). Depressive symptoms measured means Inventory Symptomatology (IDS) Beck (BAI). Using Multi-Analyte Profiling technology, plasma levels 13 assayed after whole addition LPS. Basal C-reactive protein, interleukin-6 tumor necrosis factor-α also available. A basal a LPS summary index created. Results show LPS-stimulated inflammation was associated increased odds depressive/anxiety (odds ratio (OR)=1.28, P =0.009), as case for (OR=1.28, =0.001). These associations no longer significant adjustment lifestyle health (OR=1.13, =0.21; OR=1.07, =0.45, respectively). After health, interleukin-8 both (OR=1.25, =0.02) =0.005) In addition, more severe β =0.129, <0.001) =0.165, symptoms, inflammation. Unlike inflammation, still (anxiety) symptom severity (IDS: interleukin (IL)-8, MCP-1, MMP2; BAI: index, IL-6, IL-8, IL-10, IL-18, MMP2, TNF-β). conclude, factors partly explain higher basal, well However, several positively particular even while taking into account. Elevated IL-8 previously currently depressed anxious might indicate genetic vulnerability these