Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis

• DOI: 10.1038/tp.2017.112
• Publication Date: 2017-05-30T13:41:00Z
• Authors: J-c Zhang; W Yao; C Dong; C Yang; Q Ren; M Ma; K Hashimoto
• Keywords: Social defeat; Pathogenesis; Gut–brain axis

Abstract Depression is a common, severe and chronic psychiatric disease. Although the currently available antidepressants have been used in treatment of depression, their beneficial effects are limited. Accumulating evidence suggests that pro-inflammatory cytokines such as interleukin-6 (IL-6) an important role pathogenesis depression. This study was undertaken to examine whether anti-mouse IL-6 receptor antibody (MR16-1) induces antidepressant social defeat stress model. Intravenous injection MR16-1 induced rapid-onset long-lasting susceptible mice after through its anti-inflammatory actions. In contrast, intracerebroventricular no mice. Furthermore, with could significantly normalize alterations expression synaptic proteins (postsynaptic density protein 95 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 1) dendritic spine brain regions Gut microbiota analysis using 16S ribosomal RNA gene sequencing showed improved decreased Firmicutes/Bacteroidetes ratio It also levels Oscillospira These findings suggest peripheral has key depression blockade periphery might by normalizing altered composition gut stress. Therefore, shows promise novel therapeutic approach for depressed patients higher blood levels.