Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults

• DOI: 10.1038/tp.2017.155
• Publication Date: 2017-08-15T13:42:08Z
• Authors: J A Bell; M Kivimäki; E T Bullmore; A Steptoe; ; Edward Bullmore; Petra E Vértes; Rudolf Cardinal; Sylvia Richardson; Gwenael Leday; Tom Freeman; David Hume; Tim Regan; Zhaozong Wu; Carmine Pariante; Annamaria Cattaneo; Patricia Zuszain; Alessandra Borsini; Robert Stewart; David Chandran; Livia A Carvalho; Joshua A Bell; Luis Henrique Sou...; Hugh Perry; Neil Harrison; Wayne Drevets; Gayle M Wittenberg; Yu Sun; Declan Jones; Edward Bullmore; Shahid Khan; Annie Stylianou; Robert B Henderson; L A Carvalho
• Keywords: Depression; Odds

Abstract Evidence on systemic inflammation as a risk factor for future depression is inconsistent, possibly due to lack of regard persistency exposure. We examined whether being inflamed multiple occasions increases new depressive symptoms using prospective data from population-based sample adults aged 50 years or older (the English Longitudinal Study Ageing). Participants with less than four eight in 2004/05 and 2008/09 based the Eight-item Centre Epidemiologic Studies Depression scale were analysed. The number C-reactive protein ⩾3 mg l −1 over same initial assessments (1 vs 0 occasion, 2 occasions) was relation change between 2012/13 odds developing symptomology (having more equal symptoms) 2012/13. In multivariable-adjusted regression models ( n =2068), participants who 1 occasion showed no increase nor raised symptomology; those 0.10 (95% confidence intervals (CIs)=−0.07, 0.28) symptom 1.60 CI=1.00, 2.55) times higher odds. further analyses, associated increased among women (odds ratio (OR)=2.75, 95% CI=1.53, 4.95), but not men (OR=0.70, CI=0.29, 1.68); P -for-sex interaction=0.035. this cohort study adults, repeated transient exposure women; subgroup finding requires confirmation validity.