Rapamycin biosynthesis: elucidation of gene product function

• DOI: 10.1039/b608813a
• Publication Date: 2006-08-22T12:32:44Z
• Authors: Matthew A. Gregory; Hui Hong; Rachel E. Lill; Sabine Gaisser; Hrvoje Petkovic; Lindsey Low; Lesley S. Sheehan; Isabelle Carletti; Sarah J. Ready; Michael J. Ward; Andrew L. Kaja; Alison J. Weston; Iain R. Challis; Peter F. Leadlay; Christine J. Martin; Barrie Wilkinson; Rose M. Sheridan
• Keywords: Natural product

The function of gene products involved in the biosynthesis clinically important polyketide rapamycin were elucidated by biotransformation and complementation