Toward the total synthesis of spirastrellolide A. Part 3: Intelligence gathering and preparation of a ring-expanded analogue

• DOI: 10.1039/b707835h
• Publication Date: 2007-07-19T09:45:02Z
• Authors: Alois Fürstner; Bernhard Fasching; Gregory W. O'Neil; Michaël D. B. Fen...; Cédrickx Godbout; Julien Ceccon
• Keywords: Cyclization; Indicators and Reagents; Spiro Compounds; Macrolides; 01 natural sciences; 0104 chemical sciences; 3. Good health

Different methods for the formation of C.25–C.26 bond spirastrellolide A (1) are evaluated that might qualify end game projected total synthesis, with emphasis on metathetic ways to forge macrocyclic frame.