Polycyclic framework synthesis of anominine and tubingensin A indole diterpenoids

• DOI: 10.1039/b718280e
• Publication Date: 2008-01-18T11:00:15Z
• Authors: Ben Bradshaw; Gorka Etxebarria-...; Josep Bonjoch
• Keywords: Decalin; Methylene; Methyl Ketone

A highly congested decalin embodying an α-methylene ketone is synthesized in 11 steps from the Wieland–Miescher and efficiently converted to polycyclic frameworks of anominine tubingensin A, which constitutes first approach skeleton these indole diterpenoids.